Title of article
Crystal structure of vilazodone hydrochloride methanol monosolvate
Author/Authors
Hu, Xiu-Rong Chemistry Department - Zhejiang University, People's Republic of China , Ye, Jia-Li College of Pharmaceutical Science - Zhejiang Chinese Medical University, People's Republic of China , Gu, Jian-Ming Chemistry Department - Zhejiang University, People's Republic of China
Pages
10
From page
1
To page
10
Abstract
In the title compound, C26H28N5O2+·Cl−·CH3OH {systematic name: 4-(2-carbamoyl-1-benzofuran-5-yl)-1-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-ium chloride methanol monosolvate}, the protonated piperazine ring adopts a chair conformation. The indole ring plane is nearly perpendicular to the benzofuran ring system, with a dihedral angle of 85.77 (2)°. In the crystal, the organic cations, Cl− anions and methanol solvent molecules are linked by classical N—H⋯O and N—H⋯Cl hydrogen bonds, and weak C—H⋯O and C—H⋯π interactions into a three-dimensional supramolecular architecture.
Keywords
crystal structure , hydrogen bonds , piperazine , benzofuran , indole
Journal title
Acta Crystallographica Section E: Crystallographic Communications
Serial Year
2016
Record number
2620079
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