Author/Authors :
Lyra Junior, Humberto Fenner Department of Surgery - Universitary Hospital - Universidade Federal de Santa Catarina (UFSC), Florianopolis-SC, Brazil , Rodrigues, Igor Kunze Department of Surgery - Universitary Hospital - Universidade Federal de Santa Catarina (UFSC), Florianopolis-SC, Brazil , Schiavon, Leonardo de Lucca Universitary Hospital - UFSC, Florianopolis-SC, Brazil , D`Acâmpora, Armando José Department of Surgery - Universitary Hospital - UFSC, Florianopolis-SC, Brazil
Abstract :
Healing of intestinal anastomosis remains a challenge for surgeons, mainly after colon and rectal resections. Anastomotic leakage is the most feared and potentially fatal complication after colorectal surgery because usually results in high morbidity and mortality, increase length of stay, medical costs and is associated with poorer long-term oncological results1-5. The prevalence of anastomotic leakage has been reported to range from 1 to 26%1,2,6-11. Multiple factors are involved in healing process of colorectal anastomosis, including technical-related factors and patients-specific characteristics. Over the last few years, molecular aspects of wound healing process have been described and great interest is being given in the role of hormones in the reparative process. The aim of the present review is to provide a comprehensive analysis of the role of ghrelin`s therapy in the gastrointestinal anastomotic healing mainly in colorectal procedures.
