Author/Authors :
Kamili, Asma Office National de Sécurité Sanitaire des Produits Alimentaires, Morocco , Bengoumi, Mohammed FAO Subregional Office for North Africa, Tunisia , Oukessou, Mohamed Institut Agronomique et Vétérinaire Hassan II (IAV Hassan II), Morocco , Faye, Bernard Centre de coopération internationale en recherche agronomique pour le développement (CIRAD), Campus International de Baillarguet - Environnements et sociétés (ES), France , Faye, Bernard Camel and Range Research Center, Saudi Arabia , Lefebvre, Hervé P. Université de Toulouse - Institut National Polytechnique, Ecole National Vétérinaire de Toulouse - Unité de Recherche clinique, France
Abstract :
The main objective of this study was to assess glomerular filtration rate (GFR) in the camels (Camelus dromedarius) under free water access and dehydration conditions (after a 34 days-period of water deprivation) using plasma exogenous creatinine clearance without urine collection. Trials were carried out on six nonpregnant, non-lactating and healthy female camels. Creatinine was administered as an IV bolus at a dose of 16 mg/kg body weight. Blood samples were collected at predetermined times over 24 h post-injection. Plasma creatinine concentration was analysed using Jaffé method. Creatinine clearance was calculated by pharmacokinetic analysis using a non-compartmental approach. Water deprivation induced a significant 15%- decrease in body weight but did not affect haematocrit and total plasma proteins. Mean corpuscular volume increased and red blood cells number decreased in dehydrated conditions. Dehydration produced a significant 30%-increase in plasma creatinine and mean residence time and a significant 20%-decrease in GFR. In conclusion, water deprivation decreased glomerular filtration and plasma exogenous creatinine clearance test could be used as a practical method for GFR assessment in dromedary camel in field conditions.
Keywords :
Camelus dromedarius , Creatinine , Dehydration , Glomerular filtration rate , Kidney
