Author/Authors :
Lee, Sang Hoon Department of Internal Medicine - Seoul National University Bundang Hospital - Seoul National University College of Medicine, Seongnam , Park, Byung Hoon Department of Internal Medicine - Institute of Chest Diseases - Severance Hospital - Yonsei University College of Medicine - Seoul, Korea , Song, Joo Han Department of Internal Medicine - Institute of Chest Diseases - Severance Hospital - Yonsei University College of Medicine - Seoul, Korea , Kim, Song Yee Department of Internal Medicine - Institute of Chest Diseases - Severance Hospital - Yonsei University College of Medicine - Seoul, Korea , Chung, Kyung Soo Department of Internal Medicine - Institute of Chest Diseases - Severance Hospital - Yonsei University College of Medicine - Seoul, Korea , Kim, Eun Young Department of Internal Medicine - Institute of Chest Diseases - Severance Hospital - Yonsei University College of Medicine - Seoul, Korea , Jung, Ji Ye Department of Internal Medicine - Institute of Chest Diseases - Severance Hospital - Yonsei University College of Medicine - Seoul, Korea , Kim, Young Sam Department of Internal Medicine - Institute of Chest Diseases - Severance Hospital - Yonsei University College of Medicine - Seoul, Korea , Kim, Se Kyu Department of Internal Medicine - Institute of Chest Diseases - Severance Hospital - Yonsei University College of Medicine - Seoul, Korea , Chang, Joon Department of Internal Medicine - Institute of Chest Diseases - Severance Hospital - Yonsei University College of Medicine - Seoul, Korea , Park, Moo Suk Department of Internal Medicine - Institute of Chest Diseases - Severance Hospital - Yonsei University College of Medicine - Seoul, Korea
Abstract :
Background: Despite many ongoing, prospective studies on the topic, sepsis still remains one of the main causes of death in hospital.
The hormone insulin-like growth factor 1 (IGF-1) has a similar molecular structure to that of insulin. IGF-1 exerts anabolic effects and
plays important roles in both normal physiology and pathologic processes. Previous studies have observed low serum IGF-1 level in
patients with critical illnesses. Here, we evaluated changes in IGF-1 level based on survival of septic patients.
Methods: We evaluated 140 patients with sepsis and septic shock (21 with sepsis and 119 with septic shock) admitted to the intensive
care unit of a university-affiliated hospital in Korea. Serum IGF-1 level was measured on days 0, 1, 3, and 7. Patients with liver disease
were excluded from this study. All data were analyzed using SPSS version 20 (SPSS Inc., Chicago, IL, USA).
Results: Patients with septic shock had significantly lower serum IGF-1 level on days 1 and 3 than patients without septic shock (p =
0.002 and p = 0.007, respectively). Generally, there was a negative relationship between IGF-1 and serum cortisol levels; however, this
relationship was only significant on day 3 (p = 0.029). Furthermore, renin showed significantly negative correlation with IGF-1 on day
3 (p = 0.038). IGF-1 level did not show significant difference between survivors and non-survivors.
Conclusions: Our results showed that IGF-1 was associated with septic shock, and that the IGF-1 axis is severely disrupted in septic
patients. Additionally, serum cortisol and renin levels were associated with IGF-1 level.
