Author/Authors :
Teixeira, Renan Kleber Costa Universidade do Estado do Pará (UEPA), Belem-PA, Brazil , Feijó, Daniel Haber Department of Experimental Surgery - School of Medicine - UEPA, Belem-PA, Brazil , Valente, André Lopes School of Medicine - UEPA, Belem-PA, Brazil , Carvalho, Luan Teles Ferreira de School of Medicine - Universidade Federal do Pará (UFPA), Belem-PA, Brazil , Granhen, Hícaro Donato School of Medicine - Faculdade Metropolitana da Amazônia, Belem-PA, Brazil , Petroianu, Andy Department of Surgery - School of Medicine - Universidade Federal de Minas Gerais (UFMG), Belo Horizonte-MG, Brazil , Botelho, Nara Macedo Department of Gynecology - School of Medicine - UEPA, Belem-PA, Brazil
Abstract :
Purpose:
To verify the influence of oophorectomy on lipidogram and glycemia.
Methods:
Fifty six female rats were divided into the following 7 groups (n = 8): group 1 - sham group, group 2 - oophorectomy 30 days, group 3 - oophorectomy 35 days, group 4 - oophorectomy 40 days, group 5 - oophorectomy 45 days, group 6 - oophorectomy 70 days, group 7 - oophorectomy 55 days. Animals were following by number of days according the group. Was evaluated the serum levels of glucose and lipid profile.
Results:
The oophorectomized rats presented higher glycemia. Groups 3, 4, 6 and 7 had a higher glycemia and LDL levels (except for group 6) and groups 6 and 7 had lowest levels of HDL. Group 7 had highest level of VLDL than oophorectomy groups. There was no difference in triglycerides levels.
Conclusion:
Oophorectomy was related to dyslipidemia and insulin resistance, mainly after 50th days.
Keywords :
Ovariectomy , Climacteric , Dyslipidemias , Rats
