Title of article
Synthesis and crystal structure of peptide dimethyl biphenyl hybrid C52H60N6O10·0.25H2O
Author/Authors
Nguyen, Xuan Tu Department of Chemistry - VNU University of science - Vietnam National University, Vietnam , Quynh Le, Thuy Department of Chemistry - VNU University of science - Vietnam National University, Vietnam , Thi, Tra My Bui Department of Chemistry - VNU University of science - Vietnam National University, Vietnam , Maca, Dinh Hung Department of Chemistry - VNU University of science - Vietnam National University, Vietnam , Thu Bui, Thai Thanh Department of Chemistry - VNU University of science - Vietnam National University, Vietnam
Pages
15
From page
1
To page
15
Abstract
The synthesis and crystal structure of peptide 6,6′-dimethyl biphenyl hybrid are described. The title compound was synthesized by reaction between 6,6′-dimethyl-[1,1′-biphenyl]-2,2′-dicarbonyl dichloride in CH2Cl2, amine HN–proline–phenylalanine–alanine–COOMe and Et3N at 273 K under N2 atmosphere and characterized by single-crystal X-ray diffraction. The asymmetric unit contains one peptide molecule and a quarter of a water molecule. A disorder of a methyl and methoxycarbonyl group of one alanine residue is observed with occupancy ratio 0.502 (6):0.498 (6). The structure is consolidated by intra- and intermolecular hydrogen bonds.
Keywords
crystal structure , hydrogen bonding , peptide dimethyl biphenyl hybrids , Pro-Phe-Ala
Journal title
Acta Crystallographica Section E: Crystallographic Communications
Serial Year
2020
Record number
2622869
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