Author/Authors :
Nedoszytko, Bogusław Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Lange, Magdalena Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Sokołowska-Wojdyło, Małgorzata Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Renke, Joanna Department of General and Medical Biochemistry - University of Gdansk, Poland , Trzonkowski, Piotr Department of Clinical Immunology and Transplantology - Medical University of Gdansk, Poland , Sobjanek, Michał Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Szczerkowska-Dobosz, Aneta Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Niedoszytko, Marek Department of Allergology - Medical University of Gdansk, Poland , Górska, Aleksandra Department of Pulmonology - Medical University of Gdansk, Poland , Romantowski, Jan Department of Allergology - Medical University of Gdansk, Poland , Skokowski, Jarosław Department of Oncological Surgery - Medical University of Gdansk, Poland , Kalinowski, Leszek Department of Medical Laboratory Diagnostic - Central Bank of Frozen Tissues and Genetic Specimens - Medical University of Gdansk, Poland , Nowicki, Roman Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland
Abstract :
Regulatory T cells (Treg) can be divided into two types: the natural cells (tTreg), which arise in the thymus, and the induced cells (iTreg), which are produced in peripheral tissues during immune response. The most recently published studies indicate that the supervisory functions of these cells are weakened in the pathogenesis of autoimmune and neoplastic diseases of the skin. This may be a result of the domination of other immune cells in the skin, such as Th1/Th17/Th22 and Tc1 type in psoriasis and Th2 in atopic dermatitis. The excessive activity of Treg cells can lead to immunosuppression and decrease in the number of Th1 cells, which promote the development and progression of skin cancers. In the case of cutaneous T-cell lymphomas, there are suggestions that tumor progression is associated with the acquisition of the suppressor phenotype of malignant cells. There is genetic background of Treg dysfunction in skin disorders. This article describes the types and functions of Treg cells.
Keywords :
tTreg , iTreg , Breg , FOXP3
