Author/Authors :
Carsch, Kurtis M. Department of Chemistry and Chemical Biology - Harvard University, USA , Ho, William Department of Chemistry and Chemical Biology - Harvard University, USA , Lui, Kai Hin Department of Chemistry and Chemical Biology - Harvard University, USA , Valtierra, Gregory Department of Chemistry and Chemical Biology - Harvard University, USA , Dogutan, Dilek K. Department of Chemistry and Chemical Biology - Harvard University, USA , Nocera, Daniel G. Department of Chemistry and Chemical Biology - Harvard University, USA , Zheng, Shao-Liang Department of Chemistry and Chemical Biology - Harvard University, USA
Abstract :
Palladium 2-dicyclohexylphosphanyl-2′,6′-diisopropoxybiphenyl (Pd–RuPhos) catalysts demonstrate high catalytic activity for Negishi cross-couplings of sterically hindered aryl halides, for Suzuki–Miyaura cross-couplings of tosylated olefins, and for Buchwald–Hartwig amination of sterically hindered amines. The solid-state structure of the free RuPhos ligand, C30H43O2P, is reported herein for the first time. RuPhos crystallizes in a triclinic cell containing two independent molecules of the phosphine without any lattice solvent. Pertinent bond metrics and comparisons to other phosphine ligands are presented. The structure of RuPhos will be of assistance in the use of this ligand in the design of cross-coupling catalysts.
Keywords :
RuPhos , Buchwald ligand , Buchwald ligand , crystal structure , cone angle , phosphine , Buchwald ligand
