Author/Authors :
Nedoszytko, Bogusław Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Sokołowska-Wojdyło, Małgorzata Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Renke, Joanna Department of General and Medical Biochemistry - University of Gdansk, Poland , Lange, Magdalena Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Trzonkowski, Piotr Department of Clinical Immunology and Transplantology - Medical University of Gdansk, Poland , Sobjanek, Michał Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Szczerkowska-Dobosz, Aneta Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Niedoszytko, Marek Department of Allergology - Medical University of Gdansk, Poland , Górska, Aleksandra Department of Pulmonology - Medical University of Gdansk, Poland , Romantowski, Jan Department of Allergology - Medical University of Gdansk, Poland , Skokowski, Jarosław Department of Oncological Surgery - Medical University of Gdansk, Poland , Kalinowski, Leszek Department of Medical Laboratory Diagnostic - Central Bank of Frozen Tissues and Genetic Specimens - Medical University of Gdansk, Poland , Nowicki, Roman J Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland
Abstract :
Regulatory T cells (Tregs) represent a cell type that promotes immune tolerance to autologous components and maintains immune system homeostasis. The abnormal function of Tregs is relevant to the pathogenesis of several skin diseases like psoriasis, atopic dermatitis, systemic lupus erythematosus, cutaneous T-cell lymphomas, and skin cancer and is also important in rheumatoid arthritis, diabetes and other autoimmune diseases. In this review, we will summarize the role of mutations and/or polymorphisms of genes involved in Tregs development, and functions in the pathogenesis of selected skin diseases.
