Endurance Training and Royal Jelly Consumption Effects on Dopamine in Rats with Alzheimer’s disease

Introduction: Alzheimer s disease may be a sort of amnesia with brain dysfunction that gradually degrades the patient s mental abilities. The purpose of this study was to research the effect of endurance training with royal jelly consumption on dopamine in the hippocampus tissue of Alzheimer s rats with trimethyltin. Methods: During this study, 30 rats underwent injection of 8 milligram / Kilograms trimethyltin chloride and were divided into groups of 6 rats: control, training, royal jelly consumption, and training with royal jelly consumption. 6 rats were included in the healthy control group to be evaluated the effects of Alzheimer s induction on dopamine levels. The training groups were active on the treadmill for 8 weeks. The royal jelly consumption groups received 100 milligram / Kilograms royal jelly per day peritoneally for 8 weeks. The Kolmogorov-Smirnov, one-way ANOVA, and Tukey’s post hoc tests were used to analyze the findings. (P ≤0.05). Results: Alzheimer s induction with trimethyltin toxin had a Significant Impact on reducing dopamine gene levels (P = 0.04); royal jelly, training, and training with royal jelly consumption had a significant effect on increasing dopamine gene expression levels (P = 0.001). Also, the effect of training with Royal Jelly was greater than training or royal jelly consumption alone. (P = 0.001). Introduction: Alzheimer s disease may be a sort of amnesia with brain dysfunction that gradually degrades the patient s mental abilities. The purpose of this study was to research the effect of endurance training with royal jelly consumption on dopamine in the hippocampus tissue of Alzheimer s rats with trimethyltin. Methods: During this study, 30 rats underwent injection of 8 milligram / Kilograms trimethyltin chloride and were divided into groups of 6 rats: control, training, royal jelly consumption, and training with royal jelly consumption. 6 rats were included in the healthy control group to be evaluated the effects of Alzheimer s induction on dopamine levels. The training groups were active on the treadmill for 8 weeks. The royal jelly consumption groups received 100 milligram / Kilograms royal jelly per day peritoneally for 8 weeks. The Kolmogorov-Smirnov, one-way ANOVA, and Tukey’s post hoc tests were used to analyze the findings. (P ≤0.05). Results: Alzheimer s induction with trimethyltin toxin had a Significant Impact on reducing dopamine gene levels (P = 0.04); royal jelly, training, and training with royal jelly consumption had a significant effect on increasing dopamine gene expression levels (P = 0.001). Also, the effect of training with Royal Jelly was greater than training or royal jelly consumption alone. (P = 0.001). Conclusions: Although training and royal jelly consumption improve dopamine gene expression levels in the hippocampus tissue of rats with Alzheimer s disease, the effects of training combined with royal jelly consumption appear to be greater than those of royal jelly consumption alone. Conclusions: Although training and royal jelly consumption improve dopamine gene expression levels in the hippocampus tissue of rats with Alzheimer s disease, the effects of training combined with royal jelly consumption appear to be greater than those of royal jelly consumption alone.