Author/Authors :
Chaves, Rosa Helena de Figueiredo Universidade Federal Rural da Amazônia (UFRA), Belem-PA, Brazil , Souza, Celice Cordeiro de School of Medicine - Centro Universitário do Estado do Pará (CESUPA), Belem-PA, Brazil , Furlaneto, Ismari Perini Universidade Federal do Pará (UFPA), BelemPA, Brazil , Teixeira, Renan Kleber Costa Department of Experimental Surgery - School of Medicine - Universidade do Estado do Pará (UEPA), Belem-PA, Brazil , Oliveira, Carolina Pinheiro de School of Medicine - CESUPA, Belem-PA, Brazil , Rodrigues, Emanuelle de Matos School of Medicine - CESUPA, Belem-PA, Brazil , Santos, Daniel Arthur Santos dos School of Medicine - CESUPA, Belem-PA, Brazil , Silva, Renata Cunha School of Occupational Therapy - UEPA, Belem-PA, Brazil , Penha, Nelson Elias Abrahão da School of Medicine - CESUPA, Belem-PA, Brazil , Lima, Ana Rita de UFRA, Belem-PA, Brazil
Abstract :
Purpose:
To evaluate the influence tramadol on functional recovery of acute spinal cord injury in rats.
Methods:
Ten rats were divided into two groups (n = 5). All animals were submitted by a laminectomy and spinal cord injury at eighth thoracic vertebra. In control group, the rats didn’t receive any analgesic. In tramadol group, the rats received tramadol 4mg/Kg at 12/12h until 5 days by subcutaneous. Animals were following by fourteen days. Was evaluated the Basso, Beattie, Bresnahan scale (locomotor evaluation) and Rat Grimace Scale (pain evaluation) at four periods.
Results:
There no difference between the groups in locomotor evaluation in all periods evaluated (p>0.05) and in both groups there was a partial recover of function. The tramadol group show a lower pain levels at the first, third and seventh postoperatively days when comparing to the control group.
Conclusion:
The tramadol as an analgesic agent don’t influence on functional recovery of acute spinal cord injury in rats.
Keywords :
Neuralgia , Pain , Analgesics , Rats
