• Title of article

    Febuxostat ethanol monosolvate

  • Author/Authors

    Gelbrich, Thomas University of Innsbruck - Institute of Pharmacy, Austria , Kahlenberg, Volker University of Innsbruck - Institute of Mineralogy and Petrography, Austria , Adamer, Verena Sandoz GmbH - Biochemiestrasse 10, Austria , Nerdinger, Sven Sandoz GmbH - Biochemiestrasse 10, Austria , Griesser, Ulrich J. University of Innsbruck - Institute of Pharmacy, Austria

  • Pages
    9
  • From page
    1
  • To page
    9
  • Abstract
    The title compound, 2-(3-cyano-4-iso­but­oxyphen­yl)-4-methyl-1,3-thia­zole-5-car­b­oxy­lic acid ethanol monosolvate, C16H16N2O3S·C2H6O, (I), displays inter­molecular O—H⋯O and O—H⋯N bonds in which the carboxyl group of the febuxostat mol­ecule and the hydroxyl group of the ethanol mol­ecule serve as hydrogen-bond donor sites. These inter­actions result in a helical hydrogen-bonded chain structure. The title structure is isostructural with a previously reported methanol analogue.
  • Keywords
    crystal structure , solvate , pharmaceuticals , hydrogen bonding , isostructural
  • Journal title
    Acta Crystallographica Section E: Crystallographic Communications
  • Serial Year
    2020
  • Full Text URL
    journals.iucr.org/e/issues/2020/06/00/fy2145/fy2145.pdf
  • Record number

    2623578

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2623578