Author/Authors :
Mammadov, Renad Department of Pharmacology - Faculty of Medicine - Erzincan Binali Yildirim University, Erzincan, Turkey , Suleyman, Bahadir Department of Pharmacology - Faculty of Medicine - Erzincan Binali Yildirim University, Erzincan, Turkey , Altuner, Durdu Department of Pharmacology - Faculty of Medicine - Erzincan Binali Yildirim University, Erzincan, Turkey , Demirci, Elif Department of Pathology - Faculty of Medicine - Ataturk University, Erzurum, Turkey , Cetin, Nihal Department of Pharmacology - Faculty of Medicine - Selcuk University, Konya, Turkey , Yilmaz, Adnan Department of Biochemistry - Faculty of Medicine - Recep Tayyip Erdogan University, Rize, Turkey , Baykal, Huseyin Department of Plant and Animal Breeding - Recep Tayyip Erdogan University, Rize, Turkey , Alpcan, Hilal Department of Internal Medicine - Faculty of Medicine - Erzincan Binali Yildirim University, Erzincan, Turkey , Turumtay, Emine Akyuz Department of Chemistry - Faculty of Art end Science - Recep Tayyip Erdogan University, Rize, Turkey , Suleyman, Halis Department of Pharmacology - Faculty of Medicine - Erzincan Binali Yildirim University, Erzincan, Turkey
Abstract :
Purpose:
To investigate the effects of the EtOAc extract of U. longissima which is uninvestigated previously on esophagogastric cancer induced in rats with N-methyl-N-nitro-N-nitrosoguanidin (MNNG).
Methods:
The anticancer activity of EtOAc extract of U. longissima was examined in the esophagogastric adenocarcinoma models induced in rats with MNNG. EtOAc extract of U. longissima, 50 and 100 mg/kg oral doses were administered once daily for six months. MNNG induced differentiated and undifferentiated type adenocarcinomas in the esophageal and gastric tissues of rats.
Results:
EtOAc extract of U. longissima obtained from U. longissima prevented gastric and esophageal cancerogenesis induced in rats with MNNG. EtOAc extract of U. longissima did not have a lethal effect at doses of 500, 1000 and 2000 mg/kg. The prominent anticarcinogenic activity of EtOAc extract of U. longissima 50 and 100 mg/kg suggests that it is not toxic and it is selective to the cancer tissue.
Conclusion:
This information may shed light on clinical implementation of EtOAc extract of U. longissima in future.
Keywords :
Adenocarcinoma , Acetates , Usnea , Rats
