Title of article :
Continuous dopaminergic stimulation in a patient treated with daytime Levodopa-carbidopa intestinal gel and overnight Rotigotine: a case report
Author/Authors :
Imbriani, Paola Department of Systems Medicine - University of Rome “Tor Vergata” , Rome , Italy , Schirinzi, Tommaso Department of Systems Medicine - University of Rome “Tor Vergata” , Rome , Italy , D’Elia, Alessio Department of Systems Medicine - University of Rome “Tor Vergata” , Rome , Italy , Pisani, Antonio Department of Systems Medicine - University of Rome «Tor Vergata», RRCCS Santa Lucia Foundation, Rome, Italy
Abstract :
Patients with Parkinson’s disease (PD) receiving long-term L-Dopa therapy eventually develop motor complications with unpredictable “on-off” response fluctuations and involuntary movements, leading to progressive disability. Hence, the search for alternative therapeutic choices based on continuous dopamin-ergic stimulation (CDS) becomes crucial for the treatment of advanced PD. Here, we describe the case of a 70-year-old man with a 9-year history of PD, treated with daytime levodopa-carbidopa intestinal gel (LCIG) and overnight Rotigotine transdermal patch. LCIG monotherapy significantly reduced motor fluctuations and prevented the appearance of unpredictable off periods; concurrently, overnight Rotigotine improved his sleep quality and morning akinesia. Both LCIG and Rotigotine induce CDS, which conceptually mimics physiologic striatal dopamine receptor function. Hence, they both represent a good therapeutic option for the treatment of advanced PD. (www.actabiomedica.it)
Keywords :
Parkinson’s disease , Continuous dopaminergic stimulation , levodopa/carbidopa intestinal gel in-fusion , Rotigotine, motor fluctuations , morning akinesia
Journal title :
Acta bio-medica : Atenei Parmensis
