• Title of article

    Effect of taxifolin on oxidative gastric injury induced by celiac artery ligation in rats

  • Author/Authors

    Eken, Hüseyin Department of General Surgery - Faculty of Medicine - Erzincan Binali Yildirim University, Turkey , Cimen, Orhan Department of General Surgery - Faculty of Medicine - Erzincan Binali Yildirim University, Turkey , Cimen, Ferda Keskin Department of Pathology - Faculty of Medicine - Erzincan Binali Yildirim University, Turkey , Kurnaz, Eray Department of General Surgery - Mengücek Gazi Training and Research Hospital, Erzincan, Turkey , Yildirim, Murat Department of General Surgery - Zile State Hospital, Tokat, Turkey , Tasova, Volkan Department of General Surgery - Amasya University, Turkey , Kurt, Nezahat Department of Biochemistry - Faculty of Medicine - Ataturk University, Erzurum, Turkey , Pehlivanoglu, Kamil Department of General Surgery - Faculty of Medicine - Erzincan Binali Yildirim University, Turkey , Onk, Didem Department of Anesthesiology and Reanimation - Faculty of Medicine - Erzincan Binali Yildirim University, Turkey , Bilgin, Asli Ozbek Department of Pharmacology - Faculty of Medicine - Erzincan Binali Yildirim University, Turkey

  • Pages
    9
  • From page
    1
  • To page
    9
  • Abstract
    Purpose: To examine the effect of taxifolin on I/R induced gastric injury in rats using biochemical and histopatholohical methods. Methods: Eighteen albino Wistar male rats equally grouped as; gastric I/R (I/R), 50 mg/kg taxifolin + gastric I/R (TAX+ I/R) and sham operation applied (SHAM). Ischemia induced for 1 hour, and reperfusion induced for 3 hours. Results: Oxidant parameters like, Malondialdehyde (MDA) and Hydroxyguanine (8-OHdG) were higher, whereas total glutathione (tGSH) was lower in the I/R group according to SHAM group, histopathological findings such as marked destruction, edema, and proliferated dilated congested blood vessels were observed severely in the I/R group, whereas there was not any pathological finding except mild dilated congested blood vessels in the TAX+ I/R group. Conclusion: The taxifolin can be clinically beneficial in the treatment of gastric injury due to I/R procedure.
  • Keywords
    Taxifolin , Celiac Artery , Ischemia , Reperfusion , Rats
  • Journal title
    Acta Cirurgica Brasileira
  • Serial Year
    2019
  • Full Text URL
    www.scielo.br/j/acb/a/sCVWFSbbsX4fjm5XqFjgg6w/?format=pdf&lang=en
  • Record number

    2624046

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2624046