Author/Authors :
Nedoszytko, Bogusław Chair and Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Szczerkowska-Dobosz, Aneta Chair and Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Stawczyk-Macieja, Marta Chair and Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Owczarczyk-Saczonek, Agnieszka Chair and Department of Dermatology - Sexually Transmitted Diseases and Clinical Immunology - Collegium Medicum - University of Warmia and Mazury, Olsztyn, Poland , Reich, Adam Department of Dermatology - University of Rzeszow, Poland , Bartosiñska, Joanna Chair and Department of Dermatology - Venereology and Pediatric Dermatology - Medical University of Lublin, Poland , Batycka-Baran, Aleksandra Chair and Department of Dermatology - Venereology and Allergology - Wroclaw Medical University, Poland , Czajkowski, Rafał Chair and Department of Dermatology - Sexually Transmitted Diseases and Immunodermatology - Collegium Medicum - Nicolaus Copernicus University, Bydgoszcz, Poland , Dobrucki, Iwona T Beckman Institute for Advanced Science and Technology, IL, USA , Dobrucki, Lawrence W Beckman Institute for Advanced Science and Technology, IL, USA , Górecka-Sokołowska, Magdalena Chair and Department of Dermatology - Sexually Transmitted Diseases and Immunodermatology - Collegium Medicum - Nicolaus Copernicus University, Bydgoszcz, Poland , Janaszak-Jasiecka, Anna Department of Medical Laboratory Diagnostics - Medical University of Gdansk, Gdansk, Poland , Kalinowski, Leszek Department of Medical Laboratory Diagnostics - Medical University of Gdansk, Gdansk, Poland , Krasowska, Dorota Chair and Department of Dermatology - Venereology and Pediatric Dermatology - Medical University of Lublin, Poland , Purzycka-Bohdan, Dorota Chair and Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Radulska, Adrianna Department of Pharmaceutical Biochemistry - Medical University of Gdansk, Poland , Reszka, Edyta Department of Molecular Genetics and Epigenetics - Nofer Institute of Occupational Medicine, Lodz, Poland , Samotij, Dominik Department of Dermatology - University of Rzeszow, Poland , Sobalska-Kwapis, Marta Biobank Laboratory - University of Lodz, Poland , Słominski, Andrzej Department of Dermatology University of Alabama at Birmingham, Birmingham, USA , Słominski, Radomir Department of Medicine and Microbiology - Division of Clinical Immunology and Rheumatology - University of Alabama at Birmingham, USA , Strapagiel, Dominik Biobank Laboratory - University of Lodz, Poland , Szczêch, Justyna Department of Dermatology - University of Rzeszow, Poland , Żmijewski, Michał Department of Histology - Medical University of Gdansk, Poland , Nowicki, Roman J. Chair and Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland
Abstract :
Psoriasis is a multifactorial disease in which genetic, environmental and epigenetic factors regulating gene expression play a key role. In the “genomic era”, genome-wide association studies together with target genotyping platforms performed in different ethnic populations have found more than 50 genetic susceptible markers associated with the risk of psoriasis which have been identified so far. Up till now, the strongest association with the risk of the disease has been proved for HLA-C*06 gene. The majority of other psoriasis risk SNPs are situated near the genes encoding molecules involved in adaptive and innate immunity, and skin barrier function. Many contemporary studies indicate that the epigenetic changes: histone modification, promoter methylations, long non-coding and micro-RNA hyperexpression are considered as factors contributing to psoriasis pathogenesis as they regulate abnormal keratinocyte differentiation and proliferation, aberrant keratinocytes – inflammatory cells communication, neoangiogenesis and chronic inflammation. The circulating miRNAs detected in the blood may become specific markers in the diagnosis, prognosis and response to the treatment of the disease. The inhibition of expression in selected miRNAs may be a new promising therapy option for patients with psoriasis.
