Title of article :
Effects of Centella asiatica extract and powder on hydrogen peroxide-treated Sprague-Dawley rats
Author/Authors :
Hussin, Mahanom MARDI Headquarters - Food Technology Research Centre, Malaysia , Abd. Hamid, Azizah Universiti Putra Malaysia - Faculty of Food Science and Technology - Depanment of Food Science, Malaysia , Mohamed, Suhaila Universiti Putra Malaysia - Faculty of Food Science and Technology - Department of Food Science, Malaysia , Saari, Nazamid Universiti Putra Malaysia - Faculty of Food Science and Technology - Depanment of Food Science, Malaysia , Ismail, Maznah Universiti Putra Malaysia - Institute of Bioscience - Laboratory of Molecular Biomedicine, Malaysia , Bejo, Mohd. Hair Universiti Putra Malaysia - Faculty of Veterinary Medicine - Department of Veterinary, Pathology and Microbiology, Malaysia
Abstract :
A study was conducted to investigate the effect of Centella asiatica extract and powder on dietary intake, body weight, organ weights and blood lipid peroxidation of hydrogen peroxide (H2O2)-treated male Sprague-Dawley rats. The experimental rats were fed with 0.3% (w/w) C. asiatica extract, 1.5% (w/w) C. asiatica powder, 5.0% (w/w) C. asiatica powder and 0.3% (w/w) a-tocopherol for 6 weeks. To induce oxidative stress, the rats were given drinking water spiked with 0.03% (v/v) H2O2. The amount of dietary intake, organ and body weight, and malonaldehyde (MDA) level throughout the study were monitored. Histopathological examination of selected organs was done at the end of the study. The results showed that MDA level was significantly (p 0.05) higher in the normal rats compared to treated rats. Dietary supplementation of C. asiatica (extract and powder) and a-tocopherol significantly (p 0.05) reduced lipid peroxidation in the experimental rats. However, there were no significant differences in dietary intake and histopathology observations of the organs of the rats
Keywords :
Centella asiatica , lipid peroxidation , malonaldehyde , hydrogen peroxide , Sprague , Dawley rats
Journal title :
Journal of Tropical Agriculture and Food Science
Journal title :
Journal of Tropical Agriculture and Food Science
