Title of article
Crystal structure of (1S,2R)-2-[(3R,4S)-3-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinolin-2-yl]-1,2-diphenylethanol
Author/Authors
Ali, Karim Ben Laboratoire de Recherche en Energie et Matière pour le Développement des Sciences Nucléaires - Centre National des Sciences et Technologies Nucléaires, Tunisia , Retailleau, Pascal Laboratoire de Recherche en Energie et Matière pour le Développement des Sciences Nucléaires - Centre National des Sciences et Technologies Nucléaires, Tunisia
Pages
11
From page
1
To page
11
Abstract
The synthesis and crystal structure of the title compound, C30H29NO, are
described. This compound is a member of the chiral dihydroisoquinolinederived family, used as building blocks for functional materials and as source of
chirality in asymmetric synthesis, and was isolated as one of two diastereomeric
-amino alcohols, the title molecule being found to be the (S,R) diastereoisomer. In the crystal, molecules are packed in a herringbone manner parallel to
(103) and (103) via weak C—HO and C—H(ring) interactions. Hirshfeld
surface analysis showed that the surface contacts are predominantly HH
interactions (ca 75%). The crystal studied was refined as a two-component
inversion twin.
Keywords
crystal structure , chiral β-amino alcohol , tetrahydroisoquinoline , hydrogen bond , Hirshfeld surface analysis
Journal title
Acta Crystallographica Section E: Crystallographic Communications
Serial Year
2019
Record number
2625247
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