Author/Authors :
Nowicki, Roman J Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Trzeciak, Magdalena Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Rudnicka, Lidia Department of Dermatology - Medical University of Warsaw, Poland , Szepietowski, Jacek Department of Dermatology - Venereology and Allergology - Medical University of Wroclaw, Poland , Kulus, Marek Department of Pediatric Pneumonology and Allergology - Medical University of Warsaw, Poland , Kupczyk, Maciej Department of Internal Medicine - Asthma and Allergy - Medical University of Lodz, Poland , Mastalerz-Migas, Agnieszka Department of Family Medicine - Medical University of Wroclaw, Poland , Peregud-Pogorzelski, Jaroslaw Department of Pediatrics and Pediatric Oncology - Pomeranian Medical University, Szczecin, Poland , Jahnz-Różyk, Karina Department of Internal Medicine - Pneumonology - Allergology and Clinical Immunology - Military Medical Institute, Warsaw, Poland , Narbutt, Joanna Department of Dermatology - Pediatric and Oncological Dermatology - Medical University of Lodz, Poland , Czarnecka-Operacz, Magdalena Department of Dermatology - Poznan University of Medical Sciences, Poland , Czajkowski, Rafał Department of Dermatology and Venereology - Ludwik Rydygier Collegium Medicum in Bydgoszcz - Nicolaus Copernicus University inTorun, Poland , Grubska-Suchanek, Elżbieta Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland , Krasowska, Dorota Department of Dermatology - Venereology and Pediatric Dermatology - Medical University of Lublin, Poland , Kręcisz, Beata Department of Dermatology - Faculty of Medicine and Health Sciences - Jan Kochanowski University, Kielce, Poland , Kowalewski, Cezary Department of Dermatology and Immunodermatology - Medical University of Warsaw, Poland , Lesiak, Aleksandra Department of Internal Medicine - Pneumonology - Allergology and Clinical Immunology - Military Medical Institute, Warsaw, Poland , Olszewska, Małgorzata Department of Dermatology - Medical University of Warsaw, Poland , Samochocki, Zbigniew Department of Dermatology - Medical University of Warsaw, Poland , Śpiewak, Radosław Department of Experimental Dermatology and Cosmetology - Jagiellonian University Medical College, Krakow, Poland , Wilkowska, Aleksandra Department of Dermatology - Venereology and Allergology - Medical University of Gdansk, Poland
Abstract :
Atopic dermatitis (AD) is secondary to genetic, immunological and microbiological disorders as well as epidermal barrier defects, which are the main targets of therapy. The disease proceeds with periodic exacerbations. Its development and course are influenced by numerous environmental and individual factors. In recent decades, in industrialized countries, there has been a threefold increase in the incidence of AD. There is also an increasing number of cases resistant to topical treatment. Effective treatment of AD should provide control of clinical symptoms, prevent exacerbations and improve the quality of life of patients. The multifactorial etiopathogenesis and various endotypes and phenotypes of AD justify the tendency to optimize and personalize the therapy. Currently, we recommend the use of dupilumab for the treatment of patients from 12 years of age with moderate and severe atopic dermatitis, who do not respond to topical treatment.
