Author/Authors :
Mirfeizi, Zahra Rheumatic Diseases Research Center (RDRC) - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Norouzbeigi, Nasim Nuclear Medicine Department - Razavi Hospital - Imam Reza International University, Mashhad, Iran , Sahebari, Maryam Rheumatic Diseases Research Center (RDRC) - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Jokar, Mohammad Hassan Rheumatic Diseases Research Center (RDRC) - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Rezaei Yazdi, Zahra Rheumatic Diseases Research Center (RDRC) - Ghaem Hospital - School of Medicine - Mashhad University of Medical Sciences, Mashhad, Iran , Zakavi, Rasoul Nuclear Medicine Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Shafiei, Sousan Nuclear Medicine Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Aghaee, Atena Nuclear Medicine Research Center - Mashhad University of Medical Sciences, Mashhad, Iran
Abstract :
Rheumatoid arthritis (RA) is a chronic inflammatory joint disease that causes chronic synovial inflammation. Reactor-produced β−particle emitting radionuclides is a new therapeutic strategy in the management of RA. This study was conducted in 2019 and analyzed the toxicity and feasibility of 188Re-tin colloid injection, Three-Phase Positive Bone Scan, and Refractory Knee Pain. Ten patients with RA were administered radiosynovectomy with 188Re-tin colloid. The main complications after the intervention were assessed and compared with patients’ pre-intervention condition. Patients showed alleviation of pain, tenderness, and morning stiffness after the administration of radiosynovectomy. Only one RA patient received a corticosteroid injection; the other 6 patients did not need a corticosteroid injection after radiosynovectomy. Intra-articular 188Re-tin colloid injection seems to be an effective treatment modality for refractory knee joint pain in rheumatoid arthritis patients. Thus, it is suggested as a safe and effective strategy to apply.
Keywords :
knee joint , pain , rheumatoid arthritis , 188Re-tin
