The effect of endurance training with royal jelly consumption on dopamine in the hippocampus tissue of rats with Alzheimer's disease

Alzheimer's disease is an age-related ailment that affects more and more people every day. It is a type of amnesia with brain dysfunction that gradually degrades the patient's mental abilities. The aim of the present study was to investigate the effect of endurance training with royal jelly consumption on dopamine in the hippocampus tissue of Alzheimer's rats treated with trimethyltin. In this experimental study, 30 rats underwent intraperitoneal injection of 8 mg/kg trimethyltin (TMT) chloride and after ensuring Alzheimer's disease were divided into groups of 6 subjects: control, training, royal jelly consumption, and training with royal jelly consumption. In order to investigate the effects of Alzheimer's induction on dopamine levels, 6 rats were included in the healthy control group. The training groups ran on the treadmill for eight weeks, five sessions a week, and 60 minutes each session. The royal jelly consumption groups received 100 mg/kg royal jelly per day peritoneally for eight weeks. The Kolmogorov-Smirnov, one-way ANOVA, and Tukey’s mean comparison tests were used to analyze the findings (p≤0.05). Alzheimer's induction with trimethyltin toxin had a significant effect on reducing dopamine gene expression levels (p=0.04); royal jelly, training, and training with royal jelly consumption had a significant effect on increasing dopamine gene expression levels (p=0.001). Also, training and training with royal jelly consumption had a greater effect on increasing dopamine gene expression levels than royal jelly consumption (p=0.001). Although training and royal jelly consumption improve dopamine gene expression levels in the hippocampus tissue of rats with Alzheimer's disease, the effects of training combined with royal jelly consumption appear to be greater than those of royal jelly consumption alone.