Abstract :
Coronavirus Disease 2019 (COVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), a new beta coronavirus, was officially declared a global pandemic by the World Health Organization (WHO) on March 11, 2020, after coming under the spotlight through a pneumonia outbreak in Wuhan, China, first reported on December 30, 2019. As of June 2, 2020, 6,194,533 confirmed COVID-19 cases, and 376,320 associated deaths were reported worldwide (1). The clinical investigation of COVID-19 cases shows that patients with COVID-19 are admitted to hospitals with common viral pneumonia symptoms, mostly including fever, dry cough, fatigue, sore throat, and shortness of breath (2). Hyperinflammation-associated Acute Lung Injury (ALI) is the leading cause of death among patients with severe COVID-19, and highly expressed inflammatory cytokines, including interleukin (IL)-6, IL-10, IL-1β, and Tumour Necrosis Factor-α (TNF-α) play a pivotal role in aggravating the inflammatory responses (3, 4).
