Author/Authors :
Taheri, Asma Department of Sport Physiology - Faculty of Sport Sciences - Shahid Chamran University of Ahvaz - Ahvaz, Iran , Habibi, Abdolhamid Department of Sport Physiology - Faculty of Sport Sciences - Shahid Chamran University of Ahvaz - Ahvaz, Iran , Shakeryan, Saeed Department of Sport Physiology - Faculty of Sport Sciences - Shahid Chamran University of Ahvaz - Ahvaz, Iran , Nikbakht, Masoud Department of Sport Physiology - Faculty of Sport Sciences - Shahid Chamran University of Ahvaz - Ahvaz, Iran , Tabandeh, Mohammad Reza Department of Basic Sciences - Division of Biochemistry and Molecular Biology - Faculty of Veterinary Medicine - Shahid Chamran University of Ahvaz - Ahvaz, Iran
Abstract :
The apoptotic inducing factor (AIF) level increases in the brain of patients with diabetic disease.
Objectives. This study aimed to investigate whether endurance training could alleviate apoptosis in the cerebellum of
diabetic rats. Methods. Twenty rats were randomly allocated in four groups including 1) healthy control, 2) healthy
trained, 3) diabetic, and 4) diabetic trained groups. Diabetes was induced by intraperitoneal injection a single dose of
Streptozotocin (45 mg/kg). Training programs on the treadmill were performed at moderate intensity 5 days a week
for 6 weeks. The activities apoptotic inducing factor was analyzed in cerebellum of animals at the end of experiment
by ELISA method. Results. Our results showed that following six weeks endurance exercise training decreased
cytosolic release of apoptotic inducing factor (AIF) in cerebellum of diabetic rats. Conclusion. Our results confirmed
that endurance training may be improves brain functions. Understanding mechanisms of exercise on brain functions
may lead to the development of novel therapeutic strategy for neurodegenerative disorders such as type 1 diabetes.
Keywords :
Rat , Type 1 Diabetes , Apoptotic Inducing Factor , Endurance Training
