Title of article
A new and efficient method for the synthesis of pyrazolo[3,4-d] pyrimidines catalyzed by iodine
Author/Authors
Matloubi Moghaddam ، Firouz Laboratory of Organic Synthesis and Natural Products, Department of Chemistry - Sharif University of Technology , Moafi ، Atiyeh Laboratory of Organic Synthesis and Natural Products, Department of Chemistry - Sharif University of Technology , Khodabakhshi ، Mohammad Reza Laboratory of Organic Synthesis and Natural Products, Department of Chemistry - Sharif University of Technology
From page
3305
To page
3310
Abstract
Substituents of fully new pyrazolo[3,4-d]pyrimidines were synthesized. The synthesis starts with cyanomethylphenylketone that reacts with phenyl hydrazine to produce the corresponding aminopyrazole. The latter undergoes a cyclocondensation with N,N0-bis(arylmethylidene)arylmethane, yielding the final product. Both synthetic steps are high yielding (the overall yields between 65-78%). The newly synthesized compounds were characterized by 1H NMR, 13C NMR, and elemental analysis.
Keywords
Heterocyclic compounds , Pyrazolo[3,4 , d] pyrimidines , Iodine , catalyzed reaction , Aminopyrazole, N,N0 , bis(arylmethylidene) arylmethane
Journal title
Scientia Iranica(Transactions C: Chemistry, Chemical Engineering)
Journal title
Scientia Iranica(Transactions C: Chemistry, Chemical Engineering)
Record number
2631317
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