Synthesis of new 5-aryl tetrazoline from N-2-hydrazido cyclic imides and study of biological activity

This research focused on the synthesis of some new 5-aryl tetrazoline derivatives on cyclic imides via reaction of N-(2-chloro acetyl) imides with hydrazine hydrate to give compounds (1,2). Then, compounds (1,2) reacted with different aromatic aldehydes to give Schiff bases compounds (3-10). On the other hand, compound N-(2-chloro acetyl) imides reacted with sodium azide to give compounds (11,12). And finally, react Schiff bases compounds (3-10) with compounds 11 and 12 to give the tetrazoline ring. The compounds prepared were characterized by FT-IR and some of them by 1H-NMR. The effects of the preparing compounds on some strains of bacteria and fungi were studied.