Synthesis of new heterocyclic containing azo group from 2-N-chloro acetamido creatinine and studying their biological activity

The present work include synthesized new 2-amino-4-subs. thiozole(1) from reaction of 2-N-chloro acetamido Creatinine with thiourea. Compound (1) was treated with sodium nitrate and hydrochloric acid in (0-5ºC) to form diazonium salt (2), then diazonium salt reacted with acetylacetone and hydrazine, phenyl hydrazine and 2,4-dinitrophenyl hydrazine to give pyrazole ring (4-6). On the other hand, diazonium salt was react with pyrrole in the presence of glacial acetic acid to form compound (7) and with different Schiff bases to produce compounds (8-9). Prepared compounds were measured by IR and melting point and some of them by 1HNMR and their biological activity was studied.