Title of article :
Anti-seizure activity of the aqueous leaf extract of Solanum nigrum linn (solanaceae) in experimental animals
Author/Authors :
Wannang, Noel N University of Jos - Faculty of Pharmaceutical Sciences - Department of Pharmacology, Nigeria , Anuka, Joseph A Ahmadu Bello University - Department of Pharmacology and Clinical Pharmacy, Nigeria , Kwanashie, Helen O Ahmadu Bello University - Department of Pharmacology and Clinical Pharmacy, Nigeria , Gyang, Steven S University of Jos - Faculty of Pharmaceutical Sciences - Department of Pharmacology, Nigeria , Auta, Asa University of Jos - Faculty of Pharmaceutical Sciences - Department of Pharmacology, Nigeria
Abstract :
Background: Solanum nigrum is claimed in traditional medical practice, to be useful in the treatment of epilepsy in some parts of Nigeria. Objectives:To study the anti-convulsant property of the aqueous extract of the leaves of S. nigrum in chicks, mice and rats. Method:Aqueous extracts were administered intraperitoneally, at a pre-treatment time of 30 minutes, at graded doses and animals were challenged with different types of proconvulsants. Results:The aqueous leaf extract produced a significantly (P 0.05) dose dependent protection against electrically-induced seizure in chicks and rats, pentylenetetrazole-induced seizure in mice and rats and picrotoxin-induced seizure in mice and rats.The anti- seizure property of the extract was potentiated by amphetamine. Conclusion:The result obtained in this study suggests that the leaves of this plant may possess anti-convulsant property in chicks, mice and rats.
Keywords :
Solanum nigrum , anti , seizure activity , chicks , mice , rats
Journal title :
African Health Sciences
Journal title :
African Health Sciences
