Author/Authors :
Karatas, Ahmet Abant Izzet Baysal University - Izzet Baysal Medical Faculty - Department of Obstetrics and Gynecology, Turkey , Eroz, Recep Duzce University - Medical Faculty - Department of Medical Genetics, Turkey , Albayrak, Mustafa Duzce University - Medical Faculty - Department of Obstetrics and Gynecology, Turkey , Ozlu, Tulay Abant Izzet Baysal University - Izzet Baysal Medical Faculty - Department of Obstetrics and Gynecology, Turkey , Cakmak, Bulent Gaziosmanpasha University - Medical Faculty - Department of Obstetrics and Gynecology, Turkey , Keskin, Fatih Duzce University - Medical Faculty - Department of Obstetrics and Gynecology, Turkey , karatas, a. abant izzet baysal university,department of obstetrics and gynecology, Turkey , eroz, r. department of medical genetics, Turkey , albayrak, m. department of obstetrics and gynecology, Turkey , ozlu, t. abant izzet baysal university,department of obstetrics and gynecology, Turkey , cakmak, b. department of obstetrics and gynecology, Turkey , keskin, f. department of obstetrics and gynecology, Turkey
Abstract :
Background: Recurrent miscarriage (RM) is a frequent obstetric problem. Its’ pathophysiology is poorly understood. Infections, genetic, endocrine, anatomic and immunologic problems have been suggested as causes for RM. Objective: To evaluate the frequency of chromosomal abnormalities and 3 common thrombophilic mutations in couples with RM. Methods: A retrospective data collection was performed for the results of the cytogenetic analysis of the couples and Methylenetetrahydrofolate Reductase (MTHFR) C677T, Factor V Leiden (FVL) G1691A and Prothrombin (PTm) G20210A mutations of the mother in 142 couples suffering from RM. Results: Prevalence of FVL, MTHFR, and PTm gene mutations were similar between cases shaving 2 or ≥3 abortions (P=0.528; P=0.233; P=0.375). In patients with FVL, MTHFR and PTm gene mutations, the OR’s of having ≥3 abortions when compared to having 2 abortions were 1.515 (95% CI: 0.414-5.552), 0.573 (95% CI: 0.228-1.441), and 2.848 (95% CI: 0.355-22.871). All cases with PTm mutation had ≥3 abortions and all abortions occurred between 6-8 gestational weeks. Conclusion: Chromosomal abnormalities and thrombophilic mutations (especially PTm) seem to have an important role in RM. Additional larger studies involving investigation of more genes that may have a role in pregnancy are needed to assess this association.
