Title of article
Explanation of colon cancer pathophysiology through analyzing the disrupted homeostasis of bile acids
Author/Authors
Duan, Dongfeng Fourth Military Medical University - Tangdu Hospital - Department of general surgery, China , Chen, An Fourth Military Medical University - Tangdu Hospital - Department of general surgery, China , Peng, Shujia Fourth Military Medical University - Tangdu Hospital - Department of general surgery, China , Yin, Jikai Fourth Military Medical University - Tangdu Hospital - Department of general surgery, China , Yang, Tao Fourth Military Medical University - Tangdu Hospital - Department of general surgery, China , Dong, Rui Fourth Military Medical University - Tangdu Hospital - Department of general surgery, China , Tan, Kai Fourth Military Medical University - Tangdu Hospital - Department of general surgery, China , Chen, Yafeng Fourth Military Medical University - Tangdu Hospital - Department of general surgery, China , Lu, Jianguo Fourth Military Medical University - Tangdu Hospital - Department of general surgery, China , Du, Xilin Fourth Military Medical University - Tangdu Hospital - Department of general surgery, China , duan, d. department of general surgery,tangdu hospital,fourth military medical university, China , chen, a. department of general surgery,tangdu hospital,fourth military medical university, China , peng, s. department of general surgery,tangdu hospital,fourth military medical university, China , yin, j. department of general surgery,tangdu hospital,fourth military medical university, China , yang, t. department of general surgery,tangdu hospital,fourth military medical university, China , dong, r. department of general surgery,tangdu hospital,fourth military medical university, China , tan, k. department of general surgery,tangdu hospital,fourth military medical university, China , chen, y. department of general surgery,tangdu hospital,fourth military medical university, China , lu, j. department of general surgery,tangdu hospital,fourth military medical university, China , du, x. department of general surgery,tangdu hospital,fourth military medical university, China
From page
925
To page
928
Abstract
Background: The colon plays a key role in regulating the homeostasis of bile acids. Aim: The present study aims to evaluate the influence of colon cancer towards the homeostasis of bile acids. Methods: The free and conjugated bile acids were determined using ultraperformance LC (UPLC) coupled with ABI 4000 QTRAP triple quadrupole instruments. Results: The results showed that the free bile acids in serum of patients with colon cancers tend to increase, and the conjugated bile acids tended to decrease, especially for taurolithocholate (TLCA) (p 0.001). Conclusion: The alteration of bile acids balance in colon cancers indicated the possibility of complicated diseases due to the disrupted balance of bile acids.
Keywords
Colon cancer , free bile acids , conjugated bile acids
Journal title
African Health Sciences
Journal title
African Health Sciences
Record number
2634460
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