Author/Authors :
KHALILI, HOSSEIN tehran university of medical sciences tums - Department of Pharmacotherapy, تهران, ايران , DASHTI-KHAVIDAKI, SIMIN tehran university of medical sciences tums - Faculty of Pharmacy - Department of Pharmacotherapy, تهران, ايران , JAFARI, SIROUS tehran university of medical sciences tums - Imam Referral Hospital - Department of Infectious Diseases, تهران, ايران , VAHEDI, ZAHRA tehran university of medical sciences tums - Faculty of Pharmacy - Department of Pharmacotherapy, تهران, ايران , GHAELI, PADIDEH tehran university of medical sciences tums - Roozbeh Mental Health Hospital, تهران, ايران
Abstract :
This study was designed to compare the influence of ordinary (multiple-dose) and once-dailyadministration of gentamicin on tubular nephrotoxicity based on the urinary excretion of magnesium(Mg) as an indicator for this type of side effect.Thirty-two hospitalized patients, who were assigned to receive at least 5-days treatment with gentamicinat the infectious disease ward of Imam Hospital in Tehran, were prospectively studied. Seventeen patientsreceived multiple-doses of gentamicin per day and 15 patients received once-daily regimen.At the beginning and at the end of of gentamicin therapy, blood urea, serum creatinine (Cr) and Mglevels were measured. Additionally 24-hour urine samples were collected for measurement of urinaryvolume, creatinine and Mg excretions.In both treatment groups serum Mg concentration was significantly lower and fraction excretion of(FEMg) were considerably higher at the end of gentamicin therapy compared with the beginning of thetreatment. However, the serum and urinary creatinine levels did not change significantly in the twogroups
Keywords :
Aminoglycoside nephrotoxicity , once , daily regimen , Fraction excretion of magnesium(FEMg)
