Author/Authors :
Mokaberinejad, Roshanak shahed university - Faculty of Medical Science - Department of Traditional Medicine, تهران, ايران , Zafarghandi, Nafiseh shahed university - Faculty of Medical Science - Department of Gynecology and Obstetrics, تهران, ايران , Bioos, Soodabeh tehran university of medical sciences tums - Faculty of Traditional Medicine, تهران, ايران , Hashem Dabaghian, Fataneh tehran university of medical sciences tums - Research Institute for Islamic and Complementary Medicine, تهران, ايران , Naseri, Mohsen shahed university - Traditional Medicine Clinical Trial Research center, تهران, ايران , Kamalinejad, Mohammad shahid beheshti university of medical sciences - School of Pharmacy - Department of Pharmacognosy, تهران, ايران , Amin, Gholamreza tehran university of medical sciences tums - Faculty of traditional medicine - Department of traditional pharmacy, تهران, ايران , Ghobadi, Ali tehran university of medical sciences tums - Faculty of traditional medicine - Department of traditional pharmacy, تهران, ايران , Tansaz, Mojgan shahid beheshti university of medical sciences - School of Traditional Medicine, تهران, ايران , Akhbari, Ali shahid beheshti university of medical sciences - Ashrafi Esfahani Hospital, تهران, ايران , Hamiditabar, Mohammadali Excel Diagnostics and Nuclear Oncology Centre, USA
Abstract :
Background: Amenorrhea is defined as the cessation of menses. Hormone therapy is the most common treatment. Due to the contraindications and side effects of it and the increasing demand for alternative medicine substitutes, Mentha longifolia L. was used in this study. Mentha longifolia L. is a known medication in Iranian traditional medicine to induce menstrual bleeding in women with secondary amenorrhea and oligomenorrhea. Methods: A double-blind, randomized, placebo-controlled, multicenter study was conducted in 120 women with secondary amenorrhea and oligomenorrhea. Treatment consisted of sequential oral syrup, 45 ml (15 ml three times a day) for 2 weeks. If the patients did not have menstruation after 2 weeks of taking the medication, we would wait for two more weeks. If the patients had menstruation at each stage of using the drug, we started it one week after the end of menstruation. But if the patients had not menstruate after four weeks (two-week using of drug and waiting for two more weeks), the previous steps were repeated. The drug and placebo were repeated in three cycles of menstruation. Bleeding was documented by the patient on diary cards. The primary outcome variable was the occurrence (yes/no) of bleeding during the first treatment cycle. The secondary efficacy outcome was the regularity of bleeding pattern during the three cycles of the study. Results: The number of women with bleeding during the first cycle were higher in the drug group as in the placebo group (68.3% vs. 13.6%; p 0.001). The regularity of bleeding throughout the study was markedly better in the drug group compared with those given placebo (33.3% vs. 3.3%; p 0.001). No notable complication or side effect was reported in relation to Mentha longifolia L. syrup. Conclusion: In conclusion, Mentha longifolia L. syrup is a safe, well-tolerated, and effective choice in inducing bleeding and maintaining regular bleeding in women with secondary amenorrhea and oligomenorrhea.
Keywords :
Mentha longifolia , Lamiacea , Amenorrhea , Oligomenorrhea , Iranian traditional medicine , Ehtebas tams
