Author/Authors :
Azerang, Parisa Pasteur Institute - Biotechnology Research Center - Medical Biotechnology Department, Drug Design and Bioinformatics Unit, ايران , Rezayan, Ali Hossein university of tehran - Faculty of New Science and Technology - Department of Life Science Engineering, تهران, ايران , Sardari, Soroush Pasteur Institute - Biotechnology Research Center - Medical Biotechnology Department, Drug Design and Bioinformatics Unit, ايران , Kobarfard, Farzad shahid beheshti university of medical sciences - School of Pharmacy, Phytochemistry Research Centre - Department of Medicinal Chemistry, تهران, ايران , Bayat, Mitra shahid beheshti university of medical sciences - Phytochemistry Research Centre, تهران, ايران , Tabib, Kimia shahid beheshti university of medical sciences - School of Pharmacy - Department of Medicinal Chemistry, تهران, ايران
Abstract :
Background: The emergence of multidrug-resistant strains of Mycobacterium tuberculosis (Mtb) has intensified efforts to discover novel drugs for tuberculosis (TB) treatment. Targeting the persistent state of Mtb, a condition in which Mtb is resistant to conventional drug therapies, is of particular interest. Methods: This study is focused on propargyl acetate derivatives. Eight molecules were designed based on propargyl alcohols and different acid anhydrides. Results: All the synthesized compounds and commercially available ones were evaluated for anti-tuberculosis activity. Conclusions: Inhibitors against Mtb have been identified and characterized for further development into potential novel anti-tubercular drugs.
Keywords :
Mycobacterium tuberculosis , BCG , Propargyl alcohol , Acetylenic compounds (propargyl acetate derivatives)
