Author/Authors :
Teker, M Gökhan Vakif Gureba Hospital - Department of Anesthesiology, Turkey , Özdemir, Haluk Vakif Gureba Hospital - Department of Anesthesiology, Turkey , Saidoglu, Leyla Vakif Gureba Hospital - Department of Anesthesiology, Turkey , Erkalp, Kerem Vakif Gureba Hospital - Department of Anesthesiology, Turkey , Başaranoğlu, Gökçen Vakif Gureba Hospital - Department of Anesthesiology, Turkey
Abstract :
Calcium channel blockers (CCB) are the cardiovascular medicines most commonly associated with overdose death. Amlodipine, a dihydropyridine CCB, can cause shock at overdose levels. the hemodynamic shock is likely caused by calcium channel blockade in myocardial smooth muscle and beta cells. This blockade leads to peripheral vasodilatation, hyperglycemia, hypoinsulinemia, metabolic acidosis and shock. Here we describe the use of levosimendan, a calcium sensitizing agent, to treat a 16-year old woman who ingested 500 mg of amlodipine and failed to respond to conventional therapies including calcium salts, inotrope infusions and hyperinsulinemia-euglycemia therapy.
