Title of article
Synthesis of Hydroxyl Radical Scavengers from Benzalacetone and its Derivatives
Author/Authors
Handayani, Sri State University of Yogyakarta - Faculty of Mathematics and Natural Sciences - Department of Chemical Education, Indonesia , Arty, Indyah Sulistyo State University of Yogyakarta - Faculty of Mathematics and Natural Sciences - Department of Chemical Education, Indonesia
From page
61
To page
68
Abstract
Synthesis of hydroxyl radical scavengers from benzalacetone and its derivatives has been done. Benzalacetone synthesis was done by crossed aldol condensation between benzaldehyde and acetone with 1:1 mol ratio, while dibenzalacetone in 2:1 mol ratio. Benzalacetone derivatives were synthesized by replacing benzaldehyde with its derivatives, i.e. p-anisaldehyde, veratraldehyde and cinnamaldehyde. The compounds that were active as radical scavengers based on the IC50 value from the highest level were: dibenzalacetone, veratralacetone, dicinnamalacetone, diveratralacetone and anisalacetone.
Keywords
benzalacetone and its derivatives , IC50 , hydroxyl radical scavenger
Journal title
Journal of Physical Science
Journal title
Journal of Physical Science
Record number
2636290
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