EFFECT OF 1% HYDROGEN PEROXIDE (H2O2) IN DRINKING WATER ON SOME PARAMETERS IN ADULT MALE RABBITS

The present study was undertaken to investigate the effect of 1% of H2O2 on some biochemical markers related to oxidative stress,cardiac, hepatic and thyroid functions in adult male rabbit s.Twenty adult male rabbits were divided randomly into two groups (10/group), the first (control) group and the second (T) group: animals were received 1% hydrogen peroxide (H2O2)in drinking water for one month.At the end of the experiment, fasting blood samples were drawn by cardiac puncture technique from all experimental animals for measuring : a- serum concentration of total cholesterol(TC);triacylglycerol( TAG);low density lipoprotein –cholesterol( LDL-C) ;very low density lipoprotein –cholesterol (VLDL-C) and high density lipoprotein –cholesterol (HDL-C) b- serum alanine transaminase (ALT) ;aspartate transaminase (AST) and lactate dehydrogenase (LD) activities c- albumin and globulin concentrations. d-Platelets count and prothrombin time e-serum glutathione (GSH) and malondialdehyde (MDA) concentrations. F-serum thyroid stimulating hormone (TSH), triiodothronine (T3),tetraiodothyronine(T4) and glucose concentrations. The results revealed that male rabbits receiving 1% H2O2 in drinking water for one month showed a significant increase(p 0.01) in serum TC, TAG, LDL-C, VLDL-C and MDA concentrations, ALT, AST and LD activities and platelets count, and a significant decrease (p 0.05) in serum HDL-C, GSH, albumin, globulin concentrations and prothrombin time comparing to control, besides significant decrease (p 0.05) in serum T3 T4 and significant increase (p 0.05) in serum TSH, and glucose concentration were observed. On conclusion, it has been found that exposure to1% H2O2 of exerts deleterious effect on cardiac and hepatic functions, hypothyroidism and state of oxidative stress.