Role of Oxidative Stress and Some Antioxidant Enzymes in Male Infertility

More than half of all infertile male suffer from oxidative stress. Seminal plasma have antioxidant mechanisms to suppression the reactive oxygen species. The aims of the project was to evaluate the levels of protein peroxidase, lipid peroxidase and antioxidant enzymes such as glutathione peroxidase, superoxide dismutase in blood sample of infertile male and control group. Samples were collected from 50 infertile men and 25 apparently healthy men to measure the levels of oxidative stress biomarkers: protein peroxidase (PPO), lipid peroxidase (LPO) and antioxidant enzymes: glutathione peroxidase (GPX), superoxide dismutase (SOD). Results show highly significant differences in patients with male factor infertility in PPO and LPO (76.48+9.51; 58.22+5.33) compared with control group (54.72+8.63; 39.05+4.74) respectively. While GPX and SOD enzymes levels show significant differences in patients with infertility (8.01+1.04; 12.26+2.17) compared with control group (11.23+1.74; 18.26+3.24) respectively. In conclusion oxidative stress was associated with infertility and this may help for treatment of male factor infertility by using proper antioxidants such as vitamin C, vitamin A, vitamin E and selenium.