Title of article
Serum interleukins and urinary microglobulin in children with idiopathic nephrotic syndrome
Author/Authors
Rizk, M.K. University of Banha - Faculty of Medicine - Department of Paediatrics, Egypt , El-Nawawy, A. University of Alexandria - Faculty of Medicine - Department of Paediatrics, Egypt , Abdel-Kareem, E. University of Alexandria - Faculty of Medicine - Department of Clinical Pathology, Egypt , Amer, E-S. University of Banha - Faculty of Medicine - Department of Paediatrics, Egypt , El-Gezairy, D. University of Alexandria - Faculty of Medicine - Department of Clinical Pathology, Egypt , El-Shafei, A.Z. University of Alexandria - Faculty of Medicine - Department of Paediatrics, Egypt
From page
993
To page
1002
Abstract
We studied 60 children affected with idiopathic nephrotic syndrome (INS) plus 20 age and sex matched controls. The children with INS were divided into 3 groups of 20: first presentation, remission and relapse. A complete blood picture and complete urinalysis were done. Serum interleukin (IL)-1beta, IL-6, tumour necrosis factor (TNF) and quantitative urinary beta-2-microglobulin (beta-2-m) excretion were estimated. IL-1beta and IL-6 were significantly higher in the study groups, the first presentation and relapse groups having the highest concentrations. Serum TNF concentration and urinary beta-2-m excretion were significantly higher in the first presentation and relapse groups. Serum IL-1beta, IL-6 and TNF concentrations were able to select positively (100%) the first presentation and relapse groups, while these plus urinary beta-2-m excretion selected negatively (100%) the control group
Journal title
Eastern Mediterranean Health Journal
Journal title
Eastern Mediterranean Health Journal
Record number
2637583
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