Title of article
Hexadecyl-phosphorylcholine ointment for treatment of cutaneous leishmaniasis: an animal trial
Author/Authors
Iqbal, J. University of Balochistan - Department of Pharmacy, Pakistan , Bukhari, I. University of Balochistan - Department of Pharmacy, Pakistan , Jamshid, M. University of the Punjab - Faculty of Pharmacy, Pakistan , Bashir, S. University of Balochistan - Department of Pharmacy, Pakistan , Masoom Yasinzai, M. University of Balochistan - Institute of Biochemistry, Pakistan , Anwar, M. University of Balochistan - Department of Chemistry, Pakistan
From page
685
To page
689
Abstract
A placebo-controlled trial compared 6% hexadecyl-phosphorylcholine (HePC) and 12% benzethonium chloride ointment with placebo ointment for treatment of cutaneous leishmaniasis. Cutaneous lesions were experimentally induced by inoculation with leishmania promastigotes in 60 golden hamsters. Forty (40) animals were treated with drug and 20 with placebo ointment applied twice daily for 15 days. After treatment, all lesions were significantly reduced in size in the treatment group compared with the placebo ointment. No parasites were detected in smears from 35/40 of the drug-treated lesions and no relapses occurred over 120 days of observation.
Journal title
Eastern Mediterranean Health Journal
Journal title
Eastern Mediterranean Health Journal
Record number
2638362
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