Author/Authors :
Elgammal, Maha University of Alexandria - Medical Research Institute - Hematology Department, Egypt , Mourad, Zinab University of Alexandria - Medical Research Institute - Chemical and Clinical Pathology Department, Egypt , Sadek, Nadia University of Alexandria - Medical Research Institute - Chemical and Clinical Pathology Department, Egypt , Abassy, Hadeer University of Alexandria - Medical Research Institute - Chemical and Clinical Pathology Department, Egypt , Ibrahim, Heba University of Alexandria - Medical Research Institute - Chemical and Clinical Pathology Department, Egypt
Abstract :
Background: A hypercoagulable stable has been documented in patients with β-thalassemia. However, the underlying mechanisms are multifactorial. The role of soluble protein C endothelial receptor in hemostatic derangement in these patients has not been investigated. Design and methods: Plasma soluble EPCR and markers of coagulation have been analyzed in 15 splenectomized patients (group I) and 15 non-splenectomized patients (group II). Results: We showed significantly higher levels of sEPCR in patients versus the control and in group I more than group II. Levels of sEPCR positively correlated with total leukocytic and platelet counts. No correlation could be established between sEPCR and either age or sex. Conclusion: The data indicate that high sEPCR levels could be implicated in the hemostatic derangement and endothelial cell dysfunction in patients with β-thalassemia.
