Title of article :
Evaluation of CTLA-4 Gene polymorphism SNP 49 G/ A Association with Diabetes Mellitus Type 1 in Egyptian Population
Author/Authors :
al-shehmany, ali salim alexandria university - institute of graduate studies and research (igsr) - department of biotechnology, Egypt , el- kafoury, ahmad a. alexandria university - faculty of medicine - department of pediatric, Egypt , haroun, medhat a. alexandria university - institute of graduate studies and research (igsr) - department of biotechnology, Egypt , embaby, amira m. alexandria university - institute of graduate studies and research (igsr) - department of biotechnology, Egypt
Abstract :
The (CTLA-4) encodes of the T cell receptor involved in the control of T cell proliferation and mediates T cell apoptosis. The contribution of CTLA-4 gene variants to type 1 diabetes has been analyzed in several ethnic groups. In this study, the association of CTLA-4 +49 A/G polymorphism with type 1 diabetes was investigated in Egyptian patients. Sixty type 1 diabetic patients (25 males and 35 females) and 60 healthy individuals (33 males and 27 females) subjects formed the studied populations. CTLA-4 A/G polymorphism at position 49 in exon 1 was identified using allele specific methods. Patient numbers with A/G, A/A and G/G genotypes were 45 (75.0 %), 6 (10.0 %) and 9 (15.0%) while in healthy controls, these were 48 (80.0%), 2 (3.3%) and 10 (16.7%), respectively. In conclusion, the results of this study showed that CTLA-4 +49 A/G polymorphism were not associated with susceptibility to type 1 diabetes in Egyptian population.
Keywords :
Type 1 diabetes , CTLA , 4 polymorphism , susceptibility
Journal title :
Iraqi Journal Of Science
Journal title :
Iraqi Journal Of Science
