Author/Authors :
Bayraktarogğlu, Z. University of Gaziantep - Department of Paediatrics and Transfusion Medicine, Turkey , Yılmaz, N. University of Gaziantep - Department of Biochemistry, Turkey , Çicek, H.K. University of Gaziantep - Department of Biochemistry, Turkey , Karafak, A. University of Gaziantep - Department of Biochemistry, Turkey , Gül, E. State Hospital of Zekai Tahir Burak, Turkey
Abstract :
This study investigated whether cytokine accumulation in plasma of platelet concentrates obtained from single apheresis donors was beyond the acceptable limits of white blood cell contaminattion at different storage time-points. Samples were obtained from 11 voluntary apheresis donors. All products were heavily contaminated with leukocytes. Sampling times from stored platelets were 0, 1, 3, 5 days respectively. Platelet, white blood cell counts and cytokines (IL-2R, IL-8 and TNF-α) were measured. The study found significant cytokine accumulation during 5 days of storage time in leukocyte contaminated platelet concentrates, suggesting that the platelet storage time has an effect on IL-2R levels.
