Correlation between virulence factor and biofilm formation in Proteus spp.

Urinary Tract Infection is an infection that caused by the members of the genus Proteus that depends mainly on the availability of virulence factors ;Various virulence factors including biofilm, swarming migration , polysaccharide ,heamolysin,protease, DNase, urease production weredetermined for 45Proteus isolates that obtained from clinical specimens of Urinry Tract Infection patient . The distribution of virulence factors was showed variation among the testedisolates and strain specific in most cases. All Proteus isolates showed 45 (100%)biofilm , polysaccharide andSwarming capabilities with different extents. High ureaseproduction was demonstrated in most isolates 40 (88.8%);In addition, they were abling to produce protease,DNase and heamolysin, in 30(66.6%) , 28 (62.2%) and26(57.7%) respectively. The result of susceptibility test for Proteus spp. against seven antibiotics commonly used to treat UTI infection caused by Proteus spp. ; P.mirabilis were 90% sensitive for Meropenem , 80% to Ciprofloxacin , 60% for both Cephalothin , Nitrofurantion , 50% , 40% and 30% for Amikicin, gentamicin and ceftriaxone respectively ,butP.vulgaris isolates were sensitive to 80% for Meropenem ,70% Ciprofloxacin and Nitrofurantion and sensitive to 60%,50% ,40 % and 30 % for Cephalothin, gentamicinAmikacinand ceftriaxone respectively.(This studyaimed to detect and evaluate the presence of some virulence factors in Proteus species isolates causing Urinry Tract Infection .