Title of article
Association between MethylenetetrahydrofolateReductase (MTHFR) GenePolymorphisms and breast cancer in sample of Iraqi women
Author/Authors
salman, ehab d. university of baghdad - college of science - department of biotechnology, Iraq , al bayyar, ezeddin a. university of al -anbar - college of science - department of biology, Iraq , ibrahim, reem k. university of al -anbar - college of science - department of biology, Iraq
From page
447
To page
453
Abstract
Folate metabolism is fundamental and essential for DNA structure synthesis and repair. Change in genes that participate in folate metabolism can be linked with different types of malignant tumor, Therefore, this study was conducted to find out the association between methylenetetrahydrofolatereductaseMTHFR gene polymorphisms and risk of breast cancer in a sample of Iraqi patients. One Single Nucleotide Polymorphism ( SNP) including MTHFR C677T was calculated using a tetra primer ARMS PCR experiment assay. The results explained that (MTHFR C677T) consists of three genotype (CC, CT, TT), The CC genotype was the most frequent in patients and control group ( 40.00%) and(60.00%) ,respectively, while the lowest frequency was for TT genotype(26.25%) in patients group .This study also revealed that the higher frequency 56.88 % for allele C and 43.12 % for T allele in patients group . On the other hand the Odd Ratio ( O.R.) for CC, CT , TT genotypes were 1.073, 0.862 and 1.148 respectively, and the genotypes TT show a highest O.R.
Keywords
Methylenetetrahydrofolatereductasegene , Single Nucleotide Polymorphisms , Breast cancer.
Journal title
Iraqi Journal Of Science
Journal title
Iraqi Journal Of Science
Record number
2639751
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