Biological effects of different doses of Piroxicam in albino males rats

Current study aimed to investigate the effect of piroxicam on some hematological and biochemcal parameters. For this reason forty males mature Sprage Dawlley rats were divided into four equal groups. control group administrated distilled water (G1), and three groups administrated (20mg/kg,30mg/kg,40mg/kg) body weight of piroxicam for 45 days. The results showed significant decrease (P 0.05) in hemoglobin (Hb) and packed ceq volume (PCV) in groups treated with (30,40)mg/kg of piroxicam, while the treated groups produced significant increease (P 0.05) in the total white blood cell count (WBC). On the serum biochemical porameters, Piroxicam caused increase in the level of liver enzyme amunotans ferase (ALT) and aspartate amintou (AST) Also recorded significant changes in the level of kidney function (creatinine, blood urea, uric acid). Histological studies appeared piroxicam caused more severe damage to the liver included depletion of glycoprotein, nearosis congestion, fatty change and inflammatory cell infiltration, kidney section appeared shrink of glomeruli, dilated renal tubules and necrosis were noticed in the renal tubules. Also the testes section appeared no effect in all the treatment groups except in the group which treated with piroxicam _40mg/kg) which showed thickening of somniferous tubules, shrink of leyding cells and necrosis of germ cells. This study shows that the toxic effect of piroxicam depends on time and conceutration of dose administration.