Histological study of the effect of Thyroxin and Aqueous extract of Karkade on liver in Swiss male mice

The plant Karkade (Hibiscus sabdariffa L.) has been, for many years used in different countries around the world as a culinary and therapeutic resource, it has been used as antihypertensive, anti-hypercholesterolemia and as diuretic. This study aimed to determine the effect of thyroxin and the aqueous extract of Karkade alone and together on the histological and cytological structure of the liver and the inhibitory effect of the aqueous extract of Karkade on hyperthyroidism. Forty Swiss albino mice were used in this study; animals were divided into four equal experimental groups. The experimental groups included: control group, animals treated with thyroxin, animals treated with aqueous extract of Karkade and animals treated with thyroxin and with the aqueous extract of Karkade together. Results showed that the injection of thyroxin has negative effects on the liver, and that the active compounds of aqueous extract of Karkade have an important role in the inhibition of the negative effects of thyroxi