Determination the IL-10 serum level for the T1DM al-diwanyah patients

Background: The autoimmune disease T1DM (Type 1 diabetes mellitus) consider as important endocrine disorder described by the damage of beta cells of pancreatic islets. There is confirmation the IL-10 is a significant player on both immunity arms: innate and adaptiveimmunity. This study aimed to determined the essential role of IL-10 serum in the T1DM al-diwanyah patients as a vital immune factor for prevention and treatment of T1DM.Patients and methods: A total of (33) patients (T1DM) patient. The cohort was divided into two groups according to gender (17 female, 16 male).in addition to (15) healthy control group to measure the serum level of IL-10 by ELISA. Data was evaluated by T-test analysis at (P 0.05) significant level.Results: the date displayed high significant mean of serum level for T1DM patients (424.9 ± 161.6 pg/ml) in comparative with healthy control (29.1 ± 7.1 pg/ml) at the (P 0.05) level, and could be seen from the result the serum level of IL-10 for the male group (454.8 ± 156.5 pg/ml) significantly higher than female group ( 47.4 ± 22.1 pg/ml) at the (P 0.05) level.Conclusions: In conclusion IL-10 has been acknowledged as an important pleiotropic immunomodulatory cytokines were elevated under regulation of internal environment and homeostasis and involved in maintaining immune homeostasis .