Title of article :
Antioxidant status and lipid peroxidation activity in evaluating hepatocellular damage in children
Author/Authors :
Mahdy, K.A. National Research Centre - Medical Research Division - Department of Medical Biochemistry, Egypt , Abd-El-Shaheed, A. National Research Centre - Medical Research Division - Department of Child Health, Egypt , Khadr, M.E. National Research Centre - Medical Research Division - Department of Medical Physiology, Egypt , El-Shamy, K.A.I. National Research Centre - Medical Research Division - Department of Medical Physiology, Egypt
Abstract :
Serum levels of glutathione reductase (GR), glutathione S-transferase-α (GST-α) andmalondialdehyde (MDA) were determined to evaluate their use in diagnosing hepatocellular damage in75 children with liver disease. Except for level of GR in patients with HBV, GR, GST-α and MDA wereraised significantly in patients compared with controls. At 100% specificity, the sensitivity of the 3 markersfor detecting hepatitis B virus, hepatitis C virus and schistosomiasis infection respectively were:16.7%, 100.0% and 17.7% for GR; 33.3%, 62.1% and 38.2% for GST-α; and 25.0%, 10.3% and 29.4%for MDA. GR was more sensitive in hepatitis C infection, while MDA reflected changes in liver ultrasoundand GST-α was the best indicator for histopathological changes
Journal title :
Eastern Mediterranean Health Journal
Journal title :
Eastern Mediterranean Health Journal
