Author/Authors :
Harzallah, F. La Rabta Hospital - Department of Endocrinology and Diabetology, Tunisia , Ben Brahim, A. La Rabta Hospital - Department of Endocrinology and Diabetology, Tunisia , Laadhar, L. La Rabta Hospital - Immunology Laboratory, Tunisia , Feki, M. La Rabta Hospital - Biochemistry Laboratory, Tunisia , Zitouni, M. La Rabta Hospital - Immunology Laboratory, Tunisia , Makni, S. La Rabta Hospital - Immunology Laboratory, Tunisia , Kaabachi, N. La Rabta Hospital - Biochemistry Laboratory, Tunisia , Slimane, H. La Rabta Hospital - Department of Endocrinology and Diabetology, Tunisia
Abstract :
The aim of this study in Tunisia was to classify ketosis-onset diabetes in adult patients. All patients aged ≥ 30 years without known diabetes, presenting with ketosis and admitted to our department were studied. Patients with secondary or gestational diabetes and those on corticoid therapy or with coinciding infection were excluded. The data included clinical characteristics, immunological markers and β-cell function. Of the 63 patients, islet-cell antibodies were present in 27.0%, glutamic acid decarboxylase antibodies in 25.4% and thyrosin phosphatase antibodies in 19.0%. β-cell functional reserve was preserved in 54.0%. Our results confirm that patients with ketosis-onset diabetes mellitus in adulthood are a heterogeneous group.
