Author/Authors :
Jafarzadeh, A. rafsanjan university of medical sciences - Medical School - Department of Immunology, ايران , Esmaeeli-Nadimi, A. rafsanjan university of medical sciences - Ali-ebne-Abitaleb Hospital - Department of Internal Medicine, ايران , Nemati, M. rafsanjan university of medical sciences - Medical School - Department of Immunology, ايران , Tahmasbi, M. rafsanjan university of medical sciences - Ali-ebne-Abitaleb Hospital - Department of Internal Medicine, ايران , Ahmadi, P. rafsanjan university of medical sciences - Medical School - Department of Immunology, ايران
Abstract :
To compare the serum concentrations of IgG to Helicobacter pylori and its virulence factor CagA in patients with ischaemic heart disease (IHD), we recruited 120 patients with IHD [acute myocardial infarction (AMI) (n = 60); unstable angina (UA) (n = 60)] and 60 sex- and age-matched healthy controls in this study. The seroprevalence of anti-H. pylori IgG was 86.7% in AMI, 91.7% in UA patients and 58.3% in the control group with mean titres of 33.2 U/ml [standard error (SE) 4.76], 57.96 U/ml (SE 7.54) and 25.72 U/ml (SE 4.01) respectively. The seroprevalence of anti-H. pylori in the patient groups was significantly higher than the control group. The mean levels of anti-H. pylori in the AMI and UA groups were also significantly higher than in the control group. The seroprevalence and mean titre of anti-CagA IgG did not differ significantly between patient and control groups.
