Author/Authors :
Zedan, M. University of Mansoura - Faculty of Medicine - Allergy, Respiratory and Clinical Immunology Unit, Egypt , Settin, A. University of Mansoura - Faculty of Medicine - Department of Paediatrics, Egypt , El-Chennawi, F. University of Mansoura - Faculty of Medicine - Clinical Pathology and Immunology Unit, Egypt , El-Desouky, T. University of Mansoura - Faculty of Medicine - Allergy, Respiratory and Clinical Immunology Unit, Egypt , Nasef, N. University of Mansoura - Faculty of Medicine - Department of Paediatrics, Egypt , Fouda, A. University of Mansoura - Faculty of Medicine - Department of Paediatrics, Egypt
Abstract :
This study evaluated peripheral eosinophil and serum eosinophilic cationic protein (s-ECP) levels asmarkers of asthma control. A total of 38 children with asthma (16 controlled and 22 partially controlled) were compared with 16 age- and sex-matched healthy children. Total asthma cases had higher eosinophil counts and s-ECP levels than healthy children and partially controlled asthmatics had significantly higher levels of both markers than controlled asthmatics. Controlled asthma cases showed non-significant changes in both parameters versus healthy children. A negative correlation was noted between degree of asthma control and both eosinophil counts and s-ECP levels (r = –0.60 and –0.75 respectively). s-ECP as well as peripheral eosinophil count may be helpful in the assessment of asthma control.
